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Abstract #2094

A Simple and Robust Test Object for Diffusion Kurtosis

Jonathan Phillips1, 2, Geoffrey David Charles-Edwards3

1Medical Engineering and Physics, King's College London, 124-126 Denmark Hill, London, United Kingdom; 2Institute of Life Science 2, Swansea University, Swansea, Wales, United Kingdom; 3Medical Physics, St. Thomas' Hospital, Westminster Bridge Road, London, United Kingdom

Diffusion kurtosis imaging (DKI) is an extension of conventional diffusion-weighted MRI which fits a model to diffusion b-value images from which a value of diffusion kurtosis K, the degree to which diffusion is non-Gaussian, is obtained. We present a simple and robust DKI test object based upon colloidal spheres dispersed in water. A linear relationship between concentration of spheres and kurtosis is found. DKI measurements over a period of time showed excellent reproducibility indicating the suitability of these colloidal spheres as a long term test object for DKI.