Meeting Banner
Abstract #2105

in vivo Characterisation of Colorectal Tumour Microstructure with DW-MRI

Eleftheria Panagiotaki1, Simon Walker-Samuel2, Bernard M. Siow1, 2, Peter Johnson3, Rosamund Barbara Pedley3, Mark F. Lythgoe2, Daniel C. Alexander4

1Centre for Medical Image Computing, University College London, London, United Kingdom; 2Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom; 3Cancer Institute, University College London, London, United Kingdom; 4Centre for Medical Image Computing, Dept Computer Science, University College London, London, United Kingdom


This work explores the diffusion weighted (DW) MR signal of cancer cell lines with a selection of multi-compartment diffusion models, adapting a method for diffusion model identification in brain tissue . Characterisation of colorectal cancer cells (CRC) can improve the response of the cells to treatment. Most previous cancer cell classification studies involve invasive histological methods that alter the state of the sample. This study uses DW-MRI to quantitatively characterise CRC cell lines in vivo based on their microstructure.