Abstract #2109

Distinct Cerebral Tissue Alterations in Diabetic and Hereditary Neuropathic Pain as Revealed by Voxel-Based Morphometry and Tract-Based Spatial Statistics

Arzu Ceylan Has¹, Aslihan Taskiran Sag², Cagri Mesut Temucin³, Nese Oztekin², Fikri Ak², Kader Karli Oguz⁴

¹National Magnetic Resonance Research Centre (UMRAM), Bilkent University, ANKARA, Turkey; ²Department of neurology, Ankara Numune Education and Research Hospital, ANKARA, Turkey; ³Department of Neurology, Faculty of Medicine, and Institute of Neurological Sciences and Psychiatry, Hacettepe University, ANKARA, Turkey; ⁴Department of Radiology and National Magnetic Resonance Research Centre (UMRAM), Hacettepe University and Bilkent University, ANKARA, Turkey

Neuropathic pain is caused by a lesion or a disease of the somatosensory system itself. Its usually more prominent in acquired pathologies of nerve fibers like diabetic neuropathy (DNP) despite less severe degeneration than hereditary neuropathies (HNP). On the basis of differences in etiopathogenetic mechanisms, we hypothesized that grey and white matter alterations would reveal distinct patterns in patients with DNP and HNP.