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Abstract #2113

Time Dependence of the Diffusional Kurtosis in the Human Calf Muscle

Anja Maria Marschar1, Tristan Anselm Kuder1, Bram Stieltjes2, Frederik B. Laun1, 2

1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 2Quantitative Imaging Based Disease Characterization, German Cancer Research Center (DKFZ), Heidelberg, Germany

The diffusional kurtosis (Kapp) and the apparent diffusion coefficient (Dapp) were measured in the human calf muscle. Maps of Dapp and Kapp are shown and the time dependence of both values is reported. A dependence on the diffusion direction is visible for both values, but a higher anisotropy can be observed for Dapp than for Kapp. The kurtosis decreases at longer diffusion time. Absolute values of Kapp in the muscle tissue are much smaller than in white matter tissue in the brain.