Abstract #2127

Quantitative Fiber Bundle-Driven Analysis of Diffusion MRI Data

Christian Ros¹,², Daniel Guellmar¹, Martin Stenzel², Hans-Joachim Mentzel², Jrgen R. Reichenbach¹

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, TH, Germany; ²Pediatric Radiology, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, TH, Germany

With this contribution, we presented a new method for the analysis of DTI data sets that uses fiber bundles to enhance the quantitative analysis. By utilizing fiber bundles the occurrence of adverse interpolation effects at the boundaries of white matter structures as a result of the non-linear spatial normalization is prevented. The method was used to assess hemispheric differences in selected fiber bundles using FA maps of 46 healthy volunteers. A statistical analysis was performed and correction methods were employed to deal with statistical errors. In various bundles, statistically significant differences were observed that are in line with the literature.