Correlation of Imaging Connectivity with Electrophysiological Connectivity Using Intracranial Electrodes

Stephen Jones¹, Erik B. Beall², Jorge A. Gonzalez-Martinez¹, Blessy Mathew¹, Dileep Nair¹, Imad Najm¹, Michael Phillips¹, Ken E. Sakaie¹, Myron Zhang¹

We study the correlation between diffusion weighted imaging (DWI) measures of structural brain connectivity and electrophysiological connectivity obtained from intracranial electrodes in epilepsy patients. We have collected data from four patients, each with around 150 electrode contacts implanted, and our analysis suggests that the correlation between DWI-based connectivity and electrophysiological connectivity is only modest and still uncertain, which may shape how we interpret DWI data and results.