Transient Effects in Arterial CBV Quantification

Kathrin Lorenz¹, Toralf Mildner¹, Andr Pampel¹, Harald E. Mller¹

Inflow vascular-space-occupancy (iVASO) is a non-invasive method for the quantification of absolute arterial cerebral blood volume (aCBV). The present work is purposed to investigate determining factors of aCBV measurement like slow inflow of inverted blood from small vessels and inflow of fresh, i.e. non-inverted, blood in case of short arterial transit times. Transient effects related to the blood delivery by vessels of variable size were addressed by dedicated experiments. Such effects potentially lead to biased values in the aCBV measurement and were shown to vary between different regions in the human brain.