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Abstract #2177

Perfusion Quantification Using Pseudo-Continuous Arterial Spin Labelling: The Impact of Labelling Efficiency Estimation

Magdalena Sokolska1, Xavier Golay2, David Thomas1

1Department of Brain Repair & Rehabilitation, UCL Institute of Neurology, London, UK, United Kingdom; 2Department of Brain Repair & Rehabilitation, University College London, London, UK, United Kingdom

Arterial Spin Labelling (ASL) is a non-invasive method allowing quantitative measurement of CBF. Pseudo-continuous ASL (pCASL) is considered one of the best ASL techniques due to its high SNR. However, the accurate and reproducible CBF quantification using this technique can be challenging , because the labelling efficiency of the protons (α), which measures the effectiveness of the magnetic labelling of spins, depends on a number of subject-specific factors. The aim of this study was to compare different methods of labelling efficiency estimation of pCASL and evaluate error distribution on perfusion quantification resulting from α.