Abstract #2191

Cerebral Blood Flow of Mouse Increases Upon Insulin-Induced Hypoglycemia Using the Continuous Arterial Spin Labeling Technique

Hongxia Lei¹,², Rolf Gruetter³,⁴

¹University of Geneva, Geneva, Switzerland; ²EPFL, Lausanne, Vaud, Switzerland; ³cole Polytechnique Fdrale de Lausanne, Geneva, Switzerland; ⁴University of Lausanne, Lausanne, Vaud, Switzerland

The aim of our study was to apply the continuous arterial spin labeling (CASL) technique on mouse before and during hypoglycemia at 9.4T. The elevated blood flow upon hypoglycemia was observed even when animals were under isoflurane anesthesia. This study opens possibility of investigating genetically modified models using multiple MR modalities at high magnetic fields.