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Abstract #2191

Cerebral Blood Flow of Mouse Increases Upon Insulin-Induced Hypoglycemia Using the Continuous Arterial Spin Labeling Technique

Hongxia Lei1, 2, Rolf Gruetter3, 4

1University of Geneva, Geneva, Switzerland; 2EPFL, Lausanne, Vaud, Switzerland; 3cole Polytechnique Fdrale de Lausanne, Geneva, Switzerland; 4University of Lausanne, Lausanne, Vaud, Switzerland

The aim of our study was to apply the continuous arterial spin labeling (CASL) technique on mouse before and during hypoglycemia at 9.4T. The elevated blood flow upon hypoglycemia was observed even when animals were under isoflurane anesthesia. This study opens possibility of investigating genetically modified models using multiple MR modalities at high magnetic fields.