Ashley M. Stokes1,
2, Christopher C. Quarles1, 2
1Institute
of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Radiology
and Radiological Sciences, Vanderbilt University, Nashville, TN, United
States
A combined spin- and gradient-echo (SAGE) EPI method was applied in a rat glioma model to obtain absolute ΔR2, ΔR2* and ΔR1 curves, thereby permitting derivation of dynamic susceptibility contrast (DSC) parameters. T1-insensitive estimates of R2 and R2* were acquired with SAGE and compared to conventional GE and SE DSC parameters, as well as independently measured R2 and R2*. The normal brain GE and SAGE ΔR2* curves produced similar relative cerebral blood volume (rCBV) values, while tumor leakage effects led to substantially underestimated rCBV values from the GE ΔR2* curve. Dynamic SAGE acquisition can provide improved perfusion and permeability information.