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Abstract #2195

Analysis of the Spin and Gradient Echo (SAGE) Sequence for DSC-MRI in Rat Brain Tumors

Ashley M. Stokes1, 2, Christopher C. Quarles1, 2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

A combined spin- and gradient-echo (SAGE) EPI method was applied in a rat glioma model to obtain absolute ΔR2, ΔR2* and ΔR1 curves, thereby permitting derivation of dynamic susceptibility contrast (DSC) parameters. T1-insensitive estimates of R2 and R2* were acquired with SAGE and compared to conventional GE and SE DSC parameters, as well as independently measured R2 and R2*. The normal brain GE and SAGE ΔR2* curves produced similar relative cerebral blood volume (rCBV) values, while tumor leakage effects led to substantially underestimated rCBV values from the GE ΔR2* curve. Dynamic SAGE acquisition can provide improved perfusion and permeability information.