Bolus Tracking Perfusion Imaging in Humans Using Quantitative Arterial Input Function

Elias Kellner¹, Irina Mader², Marco Reisert¹, Valerij G. Kiselev¹

We recently presented a method for a quantitative determination of the arterial input function for DSC MRI. The method was verified in the pig model. In this work, we present measurements in patients with carotid stenosis and discuss the quantitative perfusion parameters obtained with our extended technique. Obtained cerebral blood flow is compared with the whole-brain flow evaluated using phase contrast MRI measurements in large arteries. Discussion focuses on issues, which are crucial for correct perfusion evaluation, such as vascular transport effects and water relaxation properties in tissue.