Keiko Miyazaki1, David John Collins1, James A. d'Arcy1, Dow-Mu Koh2, Anwar R. Padhani3, Martin O. Leach1, Matthew R. Orton1
1CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Department of Diagnostic Radiology, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 3Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom
A recently published DSC-MRI model that includes first-pass, re-circulation and leakage components was evaluated on serially acquired brain tumour data after pre-loading with Gd-contrast. Relationships between DSC-MRI and DCE-MRI kinetic parameters were explored. The tertiary amplitude parameter a3 of the novel model, which characterizes the equilibrium phase (where BBB is intact) or leakage (where BBB is disrupted), was found to correlate strongly with the interstitial space. Results suggest it may be possible to obtain information on tumour interstitial space, in addition to blood volume, blood flow and mean transit time, from a single DSC-MRI measurement by employing this novel model.