Abstract #2244

Global Reductions in Resting-State BOLD Connectivity Reflect Widespread Decreases in MEG Connectivity

Omer Tal¹, Chi Wah Wong¹, Valur Olafsson¹, Mithun Diwakar², Roland Lee², Ming-Xiong Huang², Thomas T. Liu,¹²

¹Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States; ²Radiology, University of California, San Diego, La Jolla, CA, United States

It has been previously shown that caffeine reduces resting-state BOLD connectivity throughout the brain. However, given the complex hemodynamic nature of the BOLD signal and caffeines effects on both neural activity and the vasculature, it was not clear whether neural or vascular factors were primarily responsible for the observed connectivity changes. In this study, we employ both fMRI and magnetoencephalography (MEG) to show that caffeine-induced reductions in BOLD connectivity reflect widespread decreases in neuro-electric connectivity.