Omer Tal1, Chi Wah Wong1, Valur Olafsson1, Mithun Diwakar2, Roland Lee2, Ming-Xiong Huang2, Thomas T. Liu, 12
1Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States; 2Radiology, University of California, San Diego, La Jolla, CA, United States
It has been previously shown that caffeine reduces resting-state BOLD connectivity throughout the brain. However, given the complex hemodynamic nature of the BOLD signal and caffeines effects on both neural activity and the vasculature, it was not clear whether neural or vascular factors were primarily responsible for the observed connectivity changes. In this study, we employ both fMRI and magnetoencephalography (MEG) to show that caffeine-induced reductions in BOLD connectivity reflect widespread decreases in neuro-electric connectivity.