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Abstract #2248

A Case for Correcting Attenuation of Correlation in Resting State FMRI

Jacco A. De Zwart1, Peter van Gelderen1, Jeff H. Duyn1

1Advanced MRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

In low-noise situations the correlation between two signals is underestimated, an effect known as attenuation of correlation. This work shows that this well-established effect can lead to significant underestimation of cross-correlation in resting-state fMRI, where often the ratio between the neurogenic fluctuation of interest and noise level is less than 10. Correction of the cross-correlation value for this effect is well established and straightforward if the noise level is known.