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Abstract #2256

Effective Brain Connectivity Among Resting-State Networks : A Frequency Dependent Granger Causality Analysis

I-Jung Chen1, Yen-Hsiang Cheng2, Tzu-Cheng Chao1, 2, Ping-Hong Lai3, 4, Fu-Nien Wang5, Ming-Long Wu1, 2

1Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan; 2Institute of Medical Informatics, National Cheng Kung University, Tainan, Taiwan; 3Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 4School of Medicine, National Yang-Ming University, Taipei, Taiwan; 5Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

In general, fMRI analysis includes full spectral width (i.e., bandwidth) without looking into signal changes at different spectral frequency. For a resting-state fMRI (rsfMRI) experiment, low frequency oscillation (0.01 V 0.1Hz) of MRI signals was reported to reveal activities of resting brain networks. In this study, we examined whether effective connectivity among resting brain networks changes at different frequency band. More specifically, conditional Granger Causality (GC) analysis was performed with band pass filtered time series of resting brain networks. The results show that effective connectivity varies in different frequency bands and outflows from each resting-state network present different frequency dependent characteristics.