Abstract #2263

Within Hemisphere Connectivity Differentiates Humans from Nonhuman Primates: A Resting-State fMRI Study

Hsiao-Ying Wey¹,², Kimberly A. Phillips,¹³, Angela R. Laird¹, Peter Kochunov¹,⁴, Michael D. Davis¹, David C. Glahn,¹⁵, John Blangero⁶, Timothy O. Duong⁷, Peter T. Fox¹

¹Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; ²Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; ³Department of Psychology, Trinity University, San Antonio, TX, United States; ⁴Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD, United States; ⁵Department of Psychiatry, Yale University, Hartford, CT, United States; ⁶Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States; ⁷Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

We aim to investigate evolutionary differences of functional connectivity between humans and nonhuman primates. Specifically, we identified resting-state intrinsic connectivity networks in four primate species (humans, chimpanzees, baboons, and capuchin monkeys) spanning different levels of the evolutionary tree, and we compared similarities and discrepancies of those networks found in humans. We observed similar networks associated with primary functions in both species. Interestingly, all nonhuman primate species displayed lateralized functional networks that were strikingly similar to those observed in humans.