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Abstract #2263

Within Hemisphere Connectivity Differentiates Humans from Nonhuman Primates: A Resting-State fMRI Study

Hsiao-Ying Wey1, 2, Kimberly A. Phillips, 13, Angela R. Laird1, Peter Kochunov1, 4, Michael D. Davis1, David C. Glahn, 15, John Blangero6, Timothy O. Duong7, Peter T. Fox1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; 3Department of Psychology, Trinity University, San Antonio, TX, United States; 4Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD, United States; 5Department of Psychiatry, Yale University, Hartford, CT, United States; 6Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, United States; 7Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

We aim to investigate evolutionary differences of functional connectivity between humans and nonhuman primates. Specifically, we identified resting-state intrinsic connectivity networks in four primate species (humans, chimpanzees, baboons, and capuchin monkeys) spanning different levels of the evolutionary tree, and we compared similarities and discrepancies of those networks found in humans. We observed similar networks associated with primary functions in both species. Interestingly, all nonhuman primate species displayed lateralized functional networks that were strikingly similar to those observed in humans.