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Abstract #2265

Mapping the Mouse Brain Functional Connectivity Networks: Strain Specific Patterns

Laura-Adela Harsan1, Anna Mechling1, Neele Hbner1, Hsu-Lei Lee1, Jrgen Hennig2, Dominik von Elverfeldt1

1Medical Physics, University Medical Center, Freiburg, BW, Germany; 2Medical Physics, University Medical Center Freiburg, Freiburg, BW, Germany

The intrinsic connectional architecture of functional networks (FN) in the mouse brain remains a significantly underexplored research area. The primary goal of our study is to systematically and comparatively probe using resting state fMRI (rsfMRI) the intrinsic brain functional connectivity of two mouse strains, intensively used in the fundamental and preclinical neuroscience: the C57Bl6/N and the Balbc/J strain. Using Independent Component Analysis (ICA), partial correlation and graph theory, we identify the relevant, influential nodes in each strain and show inter-strain differences in the large scale organization of FN.