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Abstract #2267

ASL Based Functional Connectivity in Schizophrenia Relates to Disease Severity

Nadja Razavi1, Andrea Federspiel1, Thomas Dierks1, Martinus Hauf2, Kay Jann1

1Dept. of Psychiatric Neurophysiology, University Hospital of Psychiatry / University of Bern, Bern, Switzerland; 2Institut of Diagnostic and Interventional Neuroradiology, University of Bern / Inselspital, Bern, Switzerland

We measured resting-state DMN activity by pCASL based cerebral blood flow (CBF) and BOLD fMRI data in 11 patients with schizophrenia. We show that both datasets yield spatially similar DMN components and we demonstrate that the spatial similarity of a patients CBF-DMN to the respective DMN group component was negatively correlated to the PANSS positive score. In addition, pCASL provides information about the absolute perfusion of the brain and network: Increased CBF in patients DMNs (controlled for grey matter CBF), suggested a state of hyperactivity that may be relating to processing errors occurring in schizophrenia.