Xiawei Ou1,
George Andrew James2, Zhaohua Ding3, Charles M. Glasier1,
Raghu H. Ramakrishnaiah1, Jeffrey R. Kaiser4
1Radiology,
Arkansas Children's Hospital; University of Arkansas for Medical Sciences,
Little Rock, AR, United States; 2Brain Imaging Research Center,
University of Arkansas for Medical Sciences, Little Rock, AR, United States; 3Vanderbilt
University Institute of Imaging Science, Nashville, TN, United States; 4Pediatrics,
Arkansas Children's Hospital; University of Arkansas for Medical Sciences,
Little Rock, AR, United States
We performed resting state fMRI study on extremely low birth-weight (ELBW) infants randomized to groups with or without permissive hypercapnia and compared the functional connectivity in the brain to the primary visual cortex. We found decreased inter-network functional connectivity between visual cortex and motor cortex for the hypercapnic infants. Our findings suggest that hypercapnic ventilation may reduce functional connectivity between brain default networks.
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