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Abstract #2276

Activation Extent and Tissue Specificity of High-TSNR BOLD at 7T

Javier Gonzalez-Castillo1, Daniel A. Handwerker1, Colin Hoy1, Peter A. Bandettini1

1Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, United States

The sensitivity of BOLD fMRI heavily depends on temporal signal-to-noise ratio (TSNR) and versatility of the hemodynamic response model. Recent work demonstrated that with optimal TSNR and using a sufficiently versatile response model it is possible to detect wide spread activations all over the brain in response to a relatively simple visual stimulation plus attention control task using a 3T scanner and 3.75x3.75x3.8mm3 voxels. Here we extent that work on a 7T scanner to evaluate the tissue specificity of high TSNR activations and the effect of higher field strength.