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Abstract #2284

BOLD Mapping of Finger Movement Compares with the Underlying Electrophysiology; a Combined 7T fMRI and ECoG Study

Jeroen Cornelis Willem Siero1, 2, Dora Hermes1, 3, Hans Hoogduin2, Peter R. Luijten2, Nick F. Ramsey1, Natalia Petridou1, 2

1Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 3Stanford University, Stanford, CA, United States

BOLD fMRI has the potential to map activation patterns of small neuronal ensembles such as columns. However, to confirm whether BOLD activation maps reflect the underlying neuronal activity patterns, a comparison with electrophysiological data is required. Here, we investigate the spatial representation of finger movements using electrocorticography (ECoG) post-implant and presurgical BOLD fMRI at 7T in the same human subjects. We show that BOLD and high frequency ECoG maps are closely matched; movement of three individual fingers could be distinguished on a spatial span of 12 mm. These results are promising for the spatial correspondence between neuronal and vascular responses.