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Abstract #2288

Spatial Heterogeneity Analysis of Brain Activation in Epilepsy

Lalit Gupta1, Ren M.H. Besseling2, 3, Geke M. Overvliet2, 4, Paul A.M. Hofman2, 4, Anton de Louw2, Maarten Vaessen2, 3, Albert P. Aldenkamp2, 4, Shrutin Ulman1, Jacobus F.A. Jansen3, 4, Walter H. Backes3, 4

1Philips Electronics India Ltd., India; 2Epilepsy center Kempenhaeghe, Heeze, Netherlands; 3Research School for Mental Health & Neuroscience, Maastricht University, Netherlands; 4Maastricht University Medical Center, Maastricht University, Netherlands

In many brain diseases it has been observed that spatial patterns in BOLD activation maps appear more (diffusively) distributed than in healthy controls. However, measures that can quantitatively characterize this spatial distributiveness in individual subjects are lacking. We evaluated language activation maps by applying a number of conceptually different spatial heterogeneity measures of activation distribution patterns.