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Abstract #2296

A Retrospective Evaluation of Clinical Functional MRI Quality and Analysis Methods

Victoria L. Morgan1, 2, Megan Strother2, Reid C. Thompson3

1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 3Neurosurgery, Vanderbilt University, Nashville, TN, United States

Due to the high variability in the anatomy and physiology of the patients who undergo functional MRI for clinical presurgical mapping of eloquent cortex, it is difficult to determine metrics for quality evaluation and to compare different analysis strategies. In this work we show that increased motion is reflected in decreased temporal signal to noise (tSNR) in both motor and language tasks. However, when performing motor tasks the focal activation is robust across levels of tSNR, motion and analysis methods; but when performing language tasks, the activation levels and spatial maps can be significantly affected by these factors.