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Abstract #2312

Deep Brain Stimulation fMRI in Mice

Yu-Chieh Jill Kao1, Hsin-Yi Lai1, John Robert Younce1, Yen-Yu Ian Shih1

1Experimental Neuroimaging Laboraory, Department of Neurology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States, Chapel Hill, NC, United States

This is the first study demonstrating the feasibility of deep brain stimulation (DBS) fMRI in mice. Robust CBV response in the somatosensory cortex was observed during DBS at the mouse ventral posteromedial thalamus. Optimal DBS frequency was found at 20 Hz which is similar to that in rats. The proposed mouse DBS fMRI technique provides a new insight into the future investigation of DBS mechanism and assessment of DBS treatment outcome.