Yue Zhang1, Christopher B. Glielmi2, Yin Jiang3, Jing Wang1, Xiaoying Wang4, Jing Fang1, Cailian Cui3, Jisheng Han3, Xiaoping P. Hu2, Jue Zhang1
1College of Engineering, Peking University, BeiJing, China; 2Department of Biomedical Engineering, Georgia Institute of Technology / Emory University, Atlanta, GA, United States; 3Neuroscience Research Institute, Peking University, Beijing, China; 4Department of Radiology, Peking University First Hospital, Beijing, China
This study mapped brain activity elicited by high frequency electroacupuncture by simultaneously using blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) contrasts. Forty subjects participated in the study, in which twenty ones were imaged during electrical acupoint stimulation (EAS) to the left LI4 acupoint at a maximal intensity without pain, and the others with a minimal-EAS at a just detectible intensity. Both BOLD and CBF data were acquired simultaneously during alternating blocks of rest and stimulation. The results revealed concordant and complementary insights into the neural effects of EAS, including modulation of subcortical structures and limbic system.