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Abstract #2344

Cortical Activation Induced by Electrical Stimulation in Patients with Multiple Sclerosis and Foot Drop

Bader Aldebasi1, Xia Lin2, Paul M. Glover3, Richard W. Bowtell3, Cris Constantinescu4, Susan T. Francis5

1SPMMRC, School of Physics & Astronomy,, Nottingham, Nottinghamshire, United Kingdom; 2Division of Rehabilitation and ageing, Nottingham, Nottinghamshire, United Kingdom; 3SPMMRC, School of Physics & Astronomy, Nottingham, Nottinghamshire, United Kingdom; 4Division of clinical Neurology, Nottingham, Nottinghamshire, United Kingdom; 5SPMMRC, School of Physics & Astronomy, Nottingham,, Nottinghamshire, United Kingdom

Functional electrical stimulation (FES) is a technique used to elicit ankle dorsiflexion (ADF) movement by electrically stimulating the common peroneal nerve, and used in gait rehabilitation to correct foot drop. Brain activation patterns associated with Active, Passive, Electrical Stimulated (ES) and combined ES plus Active induced ADF of the affected and non-affected leg are compared in ten MS patients. For Active ADF, a significant increase is seen in secondary motor areas for the affected compared to non-affected leg, whilst for ES ADF, significantly reduced activity in the insula and SII is found for the affected leg.