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Abstract #2356

Simultaneous Acquisition of Interslice Blood Flow, Magnetization Transfer Ratio Asymmetry, and MTR

Sung-Hong Park1, 2, Jeffrey William Barker1, 3, Kyongtae Ty Bae1

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 2Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea; 3Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States

We investigated the feasibility of simultaneous mapping of interslice blood flow, MTR asymmetry, and MTR, using a recently developed method, alternate ascending/descending directional navigation (ALADDIN). The cumulative MT effects in edge slices from simulations based on a modified two-pool MT model were in agreement with empirical results . Simultaneous mapping of blood flow, MTR asymmetry, and MTR in the whole brain was feasible with ALADDIN within a clinically reasonable time of &[le]~7 min. Our proposed method provides readily a full spectrum of MR measurements useful to characterize a wide range of brain pathological conditions and functional evaluation.