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Abstract #2392

Enhancement of the Myelin Rich Regions in MR Images in the Mouse Brain in vivo Using IR-UTE with a Cryo-Coil at 9.4 T.

Weronika Piedzia1, Krzysztof Jasinski1, Katarzyna Kalita1, Boguslaw Tomanek1, 2, Wladyslaw Piotr Weglarz1

1Department of MRI, Institute of Nuclear Physics PAN, Krakow, Malopolskie, Poland; 2Department of Clinical Neurosciences and Radiology, University of Calgary, Calgary, Alberta, Canada

Efficiency of the IR-UTE pulse sequence in improving contrast to noise ratio (CNR) of myelin and other structures in mouse brain in vivo at 9.4T using standard volume coil and CryoProbe was assessed. 2D UTE and IR-UTE with two inversion recovery times (TI): 500 ms and 1000 ms were used. Positive enhancement of CNR for white matter in relation to CSF and grey matter was observed in images obtained with IR-UTE (TI = 1000 ms), when compared to 2D UTE. An increase in CNR of approximately 2.5-fold was observed using CryoProbe as compared to birdcage coil for each structure.