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Abstract #2421

in vivo Quantification of Local Transient Softening in the Juvenile Rat Brain After Cannabinod Treatment: First Indications for Neuronal Remodeling?

Simon Chatelin1, Marie Humbert-Claude2, Philippe Garteiser1, Valrie Vilgrain1, 3, Bernard E. Van Beers1, 3, Zsolt Lenkei2, Ralph Sinkus1

1U773-CRB3, INSERM, Universit Paris Diderot, Sorbonne Paris Cit, Paris, France; 2Laboratoire de Neurobiologie, ESPCI-CNRS UMR 7637, ESPCI-ParisTech, Paris, France; 3Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, France

Recent studies suggest a significant influence of type-1 cannabinod receptors (CB1R) on the puberty maturation processes. A preliminary study showed a decrease of the hippocampus elasticity after CB1R agonist injection. The aim of this study is to assess the significance and causes of this effect in the hippocampus of juvenile rats. The first step consists in the comparison of hippocampus elasticity and cerebral blood flow (CBF) values, from MRElastography (MRE) and Flow-sensitive Alternating Inversion Recovery (FAIR) perfusion imaging respectively, after CB1R activation. In a second step, the sensitivity of MRE to CBF modifications is assessed using the vasodilator nicardipine.