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Abstract #2452

A Flip-Angle-Optimized 3D FLASH Sequence for Fast Dynamic T1 Mapping

Maximilian Freiermuth1, Linus Willerding2, Maximilian F. Reiser1, Michael Peller1, Olaf Dietrich1

1Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany; 2Department of Internal Medicine III, Ludwig-Maximilians-University Hospital Munich, Munich, Germany

The purpose of the present study was to optimize and evaluate a fast three-dimensional T1 mapping approach based on the variable flip angle (VFA) technique. The proposed method requires only a single 3D FLASH data set for each time point combined with a longer baseline measurement. The optimal flip angle for the dynamic series can be shown to be α dyn,opt = arccos[(2E11)/(2E1)], which was also confirmed experimentally. The proposed single-flip-angle technique provides accurate T1 values (within 5%) in phantom measurements.