Meeting Banner
Abstract #2470

Field Dependence of Relaxivity of Gd Chelates as a Function of Macromolecular Content

Henry H. Ong1, 2, Hua Li1, 3, John C . Gore, 2

1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States; 2Department of Radiology and Radiologic Sciences, Vanderbilt University, Nashville, TN, United States; 3Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

Gd-DTPA is a common MRI contrast agent used in a variety of applications such as tumor imaging. Its T1 relaxivity (r1) is a fundamental property important for quantitative analyses. Previous studies did not address the behavior of r1 at ultra-high B0 or how r1 may be modified in the presence of realistic media to different extents at different fields which is expected from the Solomon-Bloembergen-Morgan equations. Here, we report Gd-DTPA r1 measurements as a function of macromolecular content and different high B0 (up to 15.2T) and found that the effect of macromolecular content disappears at 15.2T in agreement with theory.