Henry H. Ong1,
2, Hua Li1, 3, John C . Gore, 2
1Vanderbilt
University Institute of Imaging Science, Nashville, TN, United States; 2Department
of Radiology and Radiologic Sciences, Vanderbilt University, Nashville, TN,
United States; 3Department of Physics and Astronomy, Vanderbilt
University, Nashville, TN, United States
Gd-DTPA is a common MRI contrast agent used in a variety of applications such as tumor imaging. Its T1 relaxivity (r1) is a fundamental property important for quantitative analyses. Previous studies did not address the behavior of r1 at ultra-high B0 or how r1 may be modified in the presence of realistic media to different extents at different fields which is expected from the Solomon-Bloembergen-Morgan equations. Here, we report Gd-DTPA r1 measurements as a function of macromolecular content and different high B0 (up to 15.2T) and found that the effect of macromolecular content disappears at 15.2T in agreement with theory.
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