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Abstract #2478

Optimizing the Accuracy of T1 Mapping Accounting for RF Non-Linearities and Spoiling Characteristics in FLASH Imaging

Antoine Lutti1, Nikolaus Weiskopf1

1Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom

The accuracy of T1 maps obtained with FLASH-based Variable Flip Angle (VFA) methods is affected by residual transverse coherences, spatial inhomogeneities of the transmit field B1 and non-linearities of the RF transmit chain. Here we address all these issues simultaneously and present an acquisition protocol with very high accuracy and precision. The accuracy was improved by ~40% in-vivo compared to a conventional VFA protocol, enabling cutting-edge applications such as mapping of myeloarchitecture.