Abstract #2502

Correlation of R2 and R2* with Quantitative Susceptibility Maps in Healthy Elderly Controls

Jeam Haroldo Oliveira Barbosa¹, Saifeng Liu², Jin Tang³, Manju Liu⁴, Weili Zheng⁴, Ewart Mark Haacke²,⁴, Carlos Ernersto Garrido Salmon¹

¹Department of Phisics, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil; ²School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; ³MRI Institute for Biomedical Research, Detroit, MI, United States; ⁴Wayne State University, Detroit, MI, United States

There are a variety of means by which iron content in vivo tissue can be measured. These include but are not limited to measuring: transverse relaxation rates (R2 and R2*) and quantitative magnetic susceptibility (QSM). However, the dependency of transverse relaxation rates with water content can confound the accuracy of iron quantification if R2 or R2* are used. To overcome this limitation, magnetic susceptibility mapping has been suggested to evaluate iron deposits in neurodegenerative diseases. In this study, we evaluated the correlation between iron concentration with R2 and R2* and magnetic susceptibility in vivo in the midbrain region for seven healthy elderly subjects.