Quantitative Proton Density Mapping in Pathological Tissue: Comparison of Two Receiver Profile Correction Methods

Steffen Volz¹, Ulrike Nth¹, Alina Jurcoane², Ulf Ziemann³, Elke Hattingen², Ralf Deichmann¹

Correcting for the receiver profile (RP) of the RF coil is a crucial step in quantitative proton density (PD) mapping. Two new RP correction methods were compared for pathological tissue: (1) bias field correction method and (2) pseudo PD calculation method assuming a linear relationship between T1 and PD in white and grey matter. Results were consistent for multiple sclerosis and stroke patients (small lesions). However, differences between the two RP correction methods were found in tumour tissue with results from the pseudo PD method being more plausible.