A Method to Improve Temporal Resolution in EPR Imaging of Tissue Oxygenation

Hyungseok Jang¹, Sankaran Subramanian², Nallathamby Devashayam², Murali C. Krishna², Alan B. McMillan¹

In EPRI acquired using single-point techniques, repeated imaging experiments with differing gradient amplitudes are used to calculate spectral linewidths necessary to quantify pO₂. In this study, we propose a novel estimation method that enables direct calculation of linewidth within a single dataset. We investigate gridding reconstruction and image-based registration techniques to maintain image FOV, and enable pixelwise estimation of linewidth. In phantom experiments, we show that these methods allow quantification of pO₂ within a single dataset, which will allow temporal resolution improvements of 3x compared to existing techniques.