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Abstract #2524

A Method to Improve Temporal Resolution in EPR Imaging of Tissue Oxygenation

Hyungseok Jang1, Sankaran Subramanian2, Nallathamby Devashayam2, Murali C. Krishna2, Alan B. McMillan1

1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiation Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, United States

In EPRI acquired using single-point techniques, repeated imaging experiments with differing gradient amplitudes are used to calculate spectral linewidths necessary to quantify pO2. In this study, we propose a novel estimation method that enables direct calculation of linewidth within a single dataset. We investigate gridding reconstruction and image-based registration techniques to maintain image FOV, and enable pixelwise estimation of linewidth. In phantom experiments, we show that these methods allow quantification of pO2 within a single dataset, which will allow temporal resolution improvements of 3x compared to existing techniques.