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Abstract #2527

APT and NOE Imaging Contrasts of Glioma with Different RF Saturation Powers

Jinyuan Zhou1, 2, Xiaohua Hong1

1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We performed APT imaging and NOE imaging experiments on 9L tumor-bearing rats. The NOE effect is clearly visible at lower saturation powers and is larger in contralateral normal brain tissue. On the contrary, the APT effect is observed at relatively higher saturation powers and is larger in tumor. The NOE effect is a confounding factor for the quantification of APT and other CEST effects and may be exploited as a potentially new MR contrast.