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Abstract #2543

Feasibility of in vivo CEST Imaging of Creatine (CrCEST) at 3T

Catherine DeBrosse1, Feliks Kogan1, Mohammad Haris1, Anup Singh1, Kejia Cai1, Ravi Prakash Reddy Nanga1, Hari Hariharan1, Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

The purpose of this study was to determine the feasibility of mapping creatine (Cr) in vivo using chemical exchange saturation transfer (CEST) on routine clinical scanners (3T). Mild plantar flexion exercise on healthy human subjects led to an increase in CrCESTasym that is correlated to the change in the PCr signal measured with 31P MRS.