Abstract #2698

Quantification of Inhomogeneous Iron Oxide Uptake in a Model of AIA in Rat.

Lindsey Alexandra Crowe¹, Azza Gramoun¹, Wolfgang Wirth², Frank Tobalem³, Kerstin Grosdemange⁴, Jatuporn Salaklang⁵, Anthony Redgem⁵, Alke Petri-Fink⁶, Felix Eckstein², Heinrich Hofmann⁷, Jean-Paul Valle¹

¹Radiology / Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland; ²Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria; ³Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; ⁴Faculty of Medicine, University of Geneva, Geneva, Switzerland; ⁵Adolphe Merkle Institute, Universit de Fribourg, Fribourg, Switzerland; ⁶Adolphe Merkle Institute and Chemistry Departement, Universit de Fribourg, Fribourg, Switzerland; ⁷Institute of Materials, Powder Technology Laboratory, EPFL, Lausanne, Switzerland

We present quantification of inhomogeneous SPION uptake over a 3D volume using dUTE and customized software in a rat AIA model at 3T. The use of SPION as a contrast agent is leading development of image acquisition and analysis techniques to quantify uptake and persistence. As signal from iron oxide uptake in vivo can be inhomogeneous, quantification of both the volume and signal intensity are needed for the true extent of SPION uptake. Positive contrast dUTE imaging is used due to its concentration dependence of signal intensity for iron oxide containing regions along with validation of a semi-automated segmentation technique.