Andreas Schfer1,
Dominik Fritzsch2, Peter Gnther3, Robert Trampel1,
Robert Turner1, Karl-Titus Hoffmann2
1Max-Planck-Institute
for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Department
of Neuroradiology, University of Leipzig, Leipzig, Germany; 3Department
of Neurology, University of Leipzig, Leipzig, Germany
This study investigates whether copper accumulation in the brain of Wilson’s patients can be detected using QSM. We have measured 8 patients with Wilson’s disease and 10 age-matched healthy controls. Our data clearly show that the substantia nigra is more paramagnetic in Wilson’s disease patients compared to healthy controls. There is a trend that paramagnetic copper(II) induces the magnetic susceptibility changes in patients.
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