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Abstract #2854

Quantitative Susceptibility Mapping (QSM) in Wilson&[prime]s Disease

Andreas Schfer1, Dominik Fritzsch2, Peter Gnther3, Robert Trampel1, Robert Turner1, Karl-Titus Hoffmann2

1Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Department of Neuroradiology, University of Leipzig, Leipzig, Germany; 3Department of Neurology, University of Leipzig, Leipzig, Germany

This study investigates whether copper accumulation in the brain of Wilson’s patients can be detected using QSM. We have measured 8 patients with Wilson’s disease and 10 age-matched healthy controls. Our data clearly show that the substantia nigra is more paramagnetic in Wilson’s disease patients compared to healthy controls. There is a trend that paramagnetic copper(II) induces the magnetic susceptibility changes in patients.