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Abstract #2870

Mapping the Alzheimers Structural Connectome: Findings from the Alzheimer Disease Neuroimaging Initiative

Jeffrey William Prescott1, Arnaud Guidon2, Chunlei Liu2, Allen Song2, Murali Doraiswamy3, Jeffrey Petrella1, for the Alzheimers Disease Neuroimaging Initiative1

1Radiology, Duke University, Durham, NC, United States; 2Brain Imaging Analysis Center, Duke University, Durham, NC, United States; 3Psychiatry & Behavioral Sciences, Duke University, Durham, NC, United States

The current analysis was designed to evaluate changes in the structural connections in the brain, as assessed by connectome mapping from diffusion tensor imaging (DTI) MR scans, among normal controls (NC), subjects with mild cognitive impairment (MCI), and subjects with AD in the Alzheimer's Disease Neuroimaging Intiative 2 (ADNI2). There were 101 ADNI2 subjects in the analysis. The bilateral insula weighted degree were significantly associated clinical diagnosis.