Abstract #2905

Subcortical Versus Cortical Effects of Anesthesia on Blood Oxygenation: in vivo Evidence from UHF MRI

Luisa Ciobanu¹, Lynn Uhrig², Boucif Djemai¹, Denis Le Bihan¹, Bchir Jarraya²,³

¹Neurospin, CEA, Gif sur Yvette, France; ²Equipe Avenir INSERM Bettencourt Schueller, Neurospin, CEA, Gif sur Yvette, France; ³Unit de Neurochirurgie Fonctionnelle, Henri-Mondor Hospital, Crteil, France

The non-invasive, in vivo monitoring of the effects of anesthetic agents on brain blood oxygenation remains highly challenging. Even when the systemic hemodynamics is kept stable, anesthetic agents can locally affect the cerebral hemodynamics and metabolism. Taking advantage of the increase in T2* contrast provided by UHF MRI (17.2 T) we study the effects of different anesthetic agents (isoflurane, propofol, midazolam, sevoflurane, ketamine and medetomidine) on the blood oxygenation in subcortical and cortical regions in a rat animal model.