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Abstract #2913

Across-Session Reproducibility of DTI Derived Metrics Measured at 3T: PharmaCog Consortium

Jorge Jovicich1, Moira Marizzoni2, Roser Sala-Llonch3, Nuria Bargall3, David Bartrs-Faz3, Jennifer Arnold4, Jens Benninghoff4, Jens Wiltfang4, Luca Roccatagliata5, Flavio Nobili5, Christian Zeeh6, Peter Schonknecht6, Giada Zoccatelli7, Franco Alessandrini7, Alberto Beltramello7, Hlne Gros-Dagnac8, Pierre Payoux8, Valrie Chanoine9, Jean-Philippe Ranjeva9, Mira Didic9, Melanie Leroy10, Regis Bordet10, Giovanni Frisoni2

1University of Trento, Center for Mind/Brain Sciences, Mattarello, Trento, Italy; 2IRCCS San Giovanni di Dio Fatebenefratelli, LENITEM Lab of Epidem., Neuroim. & Telem, Brescia, Lombardia, Italy; 3Dept. Psychiatry and Clinical Psychobiology, Faculty of Medicine University of Barcelona, Barcelona, Spain; 4Department of Psychiatry and nuclear medicine, Universitaet Duisburg-Essen, Essen, Germany; 5Dept of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Lombardia, Italy; 6Dept of Psychiatry and Dept of Neuroradiology, University of Leipzig, Leipzig, Germany; 7Dept of Neuroradiology, Verona General Hospital, Verona, Italy; 8U825 - Plateau Technique IRM, INSERM / Universit Paul Sabatier, Toulouse, France; 9Hpital La Timone CIC UPCET, Marseille, France; 10Universit Lille UL2, Lille, France

Multi-site longitudinal diffusion MRI studies are of interest in the search for biomarkers that can reliably predict disease progression and/or therapeutic treatment effects. Previous multi-site 3T MRI studies evaluating across-session reproducibility are limited to few sites or to long dedicated acquisitions with multiple DTI averages. In this study we evaluate and compare across-session test-retest reproducibility of fractional anisotropy, mean, axial and radial diffusivities across eight different 3T MRI sites (Siemens, Philips, GE), on a group of healthy elderly subjects, using a single DTI acquisition that is part of a protocol aimed at studying other anatomical and functional parameters.