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Abstract #2917

Pulsed Arterial Spin Labeling for CBF MRI in Non-Human Primate Model of Stroke

Kai-Hsiang Chuang1, Elaine Manigbas2, Douglas Collins2, Flordeliza de Villa2, Rosario Perez2, Lynn Collura2

1Magnetic Resonance Imaging Group, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore; 2Maccine Pte Ltd, Singapore, Singapore

We assessed using pulsed ASL for CBF measure in a middle cerebral artery occlusion (MCAO) model in the cynomolgus macaque. PICORE ASL was applied before and 24 hours after 3-hour transient MCAO. Good perfusion signal was obtained in all animals and showed extensive reduction of CBF comparable to ADC. However the large variation and very long transit time leaded to hyperintensity in artery and underestimation of CBF. Very long inversion time would be needed to quantify the CBF in this model.