Pulsed Arterial Spin Labeling for CBF MRI in Non-Human Primate Model of Stroke

Kai-Hsiang Chuang¹, Elaine Manigbas², Douglas Collins², Flordeliza de Villa², Rosario Perez², Lynn Collura²

We assessed using pulsed ASL for CBF measure in a middle cerebral artery occlusion (MCAO) model in the cynomolgus macaque. PICORE ASL was applied before and 24 hours after 3-hour transient MCAO. Good perfusion signal was obtained in all animals and showed extensive reduction of CBF comparable to ADC. However the large variation and very long transit time leaded to hyperintensity in artery and underestimation of CBF. Very long inversion time would be needed to quantify the CBF in this model.