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Abstract #2919

Assessment of Pharmacologically Induced Hypothermia Treatment in a Rodent Model of Focal Cerebral Ischemia by Using Diffusion Tensor Imaging

Silun Wang1, Xiaohuan Gu2, Ko-Eun Choi2, Yumei Yan1, Ling Wei2, Shan-Ping Yu2, Xiaodong Zhang1

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 2Department of Anesthesiology and Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States

We evaluated the pharmacologically induced hypothermia treatment response in focal cerebral ischemia induced white matter injury in a mice model using DTI. Results indicated that significantly reduced infraction volume in the treatment group compared to control group. Significantly decreased FA and λ// were only found in the ipsilateral external capsule and fornix than contralateral sides in control group. Less reduction of FA and λ// were found in the hypothermia treated group. Our results support the use of DTI as a biomarker to non-invasively monitor the hypothermia treatment response in ischemia induced stroke injury.