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Abstract #2927

Differences in Iron Particle Enhanced MRI of Brain and Spinal Cord Lesions in MOG-Induced Eae Mice

Xiaowei Zhang1, Bill Siders2, Xiaoyou Ying2, Russell E. Jacobs1

1Biological Imaging Center, California Institute of Technology, Pasadena, CA, United States; 2R&D Hub, Sanofi Boston, Boston, MA, United States

Brain and spinal cord EAE (experimental allergic encephalomyelitis) lesions in MOG35-55 induced EAE mice were imaged using a T2* weighted FLASH protocol at pre and post iron injection throughout the time course EAE acquisition. EAE lesions in the brain and spinal cord could be readily identified prior to iron injection. Comparison between the pre and post iron images revealed that administration of Feraheme had limited ability to improve MRI lesion detection.