Differences in Iron Particle Enhanced MRI of Brain and Spinal Cord Lesions in MOG-Induced Eae Mice

Xiaowei Zhang¹, Bill Siders², Xiaoyou Ying², Russell E. Jacobs¹

Brain and spinal cord EAE (experimental allergic encephalomyelitis) lesions in MOG35-55 induced EAE mice were imaged using a T2* weighted FLASH protocol at pre and post iron injection throughout the time course EAE acquisition. EAE lesions in the brain and spinal cord could be readily identified prior to iron injection. Comparison between the pre and post iron images revealed that administration of Feraheme had limited ability to improve MRI lesion detection.