Abstract #2953

Developmental Trajectories of Global OEF, CBF, CMRO2 Using Susceptibility-Based Oximetry, Phase Contrast MRI and ASL

Mayank A. Jog¹, Emily Kilroy², Varsha Jain³, Felix Wehrli³, Danny J.J. Wang²

¹Biomedical Engineering, University of California Los Angeles, Los Angeles, CA, United States; ²Neurology, University of California Los Angeles, Los Angeles, CA, United States; ³Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, United States

This study explored the developmental trajectories of global oxygen extraction fraction (OEF), cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) in 47 children aged 7 to 17. A novel non-invasive MRI method was utilized including susceptometry to quantify OEF, phase-contrast (PC) MRI to quantify CBF and Ficks principle for CMRO2. CBF and CMRO2 were found to decrease with age while OEF did not vary with age. PC measurements of global CBF were positively correlated with pseudo-continuous ASL measurements, lending support to the validity of this method.