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Abstract #2957

Coupling DTI and Histological Analysis to Examine the Multiple Layers of the Human Fetal Brain Cerebral Wall

Hao Huang1, Tina Jeon1, Linda J. Richards2

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2The Queesland Brain Institute, The University of Queesland, Brisbane, Queesland, Australia

The cerebral wall of human fetal brain is the place where active molecular and cellular activities take place during 2nd trimester fetal development, resulting in distinctive microstructures in different layers. High contrasts from DTI and histological staining are complementary to provide insight on microstructural configuration of different layers of the cerebral wall. In this study, we coupled quantitative measures from high resolution DTI data from postmortem 2nd trimester human fetal brain DTI and histology stained with hematoxylin or immunohistochemically labeled with anti-glial fibrillary acidic protein and neurofilament antibody. Differential FA values across the cerebral wall layers were quantified.