Jeong-Won Jeong1, 2, Eishi Asano1, 2, Diane C. Chugani, 23, Harry T. Chugani, 24
1Pediatrics and Neurology, Wayne State University, Detroit, MI, United States; 2PET center, Children's Hospital of Michigan, Detroit, MI, United States; 3Pediatrics and Radiology, Wayne State University, Detroit, MI, United States; 4Pediatrics, Neurology, and Radiology, Wayne State University, Detroit, MI, United States
Epilepsy is one of the most common neurologic disorders restricting the quality of life in affected individuals. The current gold standard for identifying primary motor areas in children with epilepsy is electrical stimulation mapping (ESM) which, however, is invasive and often not adequately sensitive in young children. To investigate whether DWI tractography can provide automatic localization of cortical areas and white matter pathways associated with movement of mouth/lip, fingers, and legs, the present study proposed a new method, a maximum a posteriori probability classification using neural connectivity of the cortico-spinal tract between precentral gyrus and posterior limb of internal capsule.