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Abstract #2979

Evaluation of Multi-Component Diffusion Coeffcients in Pediatric Gliomas

He Wang1, Guang Cao, Yuhua Li2, Xiujie Duan2

1MR Research China, GE Healthcare, Shanghai, China; 2Radiology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China

In this study, detailed diffusion measurements of pediatric glioma using multiple b-factors ranging up to 4000 s/mm2 have been made. 17 children with brain tumors underwent brain MR examinations at 3T scanner. Results showed that the biexponential and stretched-exponential model can all meet the WHO classification of the pediatric gliomas in the brain more accurately than the standard ADC. Multi-exponential diffusion decay functions are required for diffusion signal decay curves when sampled over an extended b-factor range, providing additional, unique tissue characterization parameters for pediatric gliomas in the brain.