Measurement of Hemodynamic Parameters in Carotid Occlusive Disease Using Partial Volume Corrected PCASL fMRI

Iris Asllani¹, Shazia Dharssi¹, Marykay Pavol¹, Ronald L. Lazar¹, Randolph S. Marshall¹

There is converging evidence that cerebral hemodynamic failure affects cognitive function in carotid artery disease, but inconsistent methods of measuring both the behavioral and the hemodynamic state have hindered this line of inquiry from influencing clinical management. Here, we present preliminary data from patients with 100% carotid stenosis on whom we measured hemodynamic parameters such as baseline and activation CBF as well as arterial transit times (ATT) using PCASL fMRI.